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On-site

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Predictive Modelling

Directed Evolution

Pathway Assembly

High-throughput Analytics

Robotic Platforms

UK_UNIMAN-SYNBNIOCHEM_DBTL

SYNBIOCHEM

Units of access: week

Quantity offered: 10

Total offered: 32

About the Platform 

The SYNBIOCHEM Centre is harnessing the power of predictive Synthetic Biology (SynBio) to develop faster, more predictable, novel routes for fine and speciality chemicals production to deliver new chemical diversity towards scale-up and industrial manufacturing.

Current research in the Centre is focused on fine and speciality chemicals production. The discovery pipeline we have created can be applied to diverse chemical space (towards “dial-a-molecule”) which would test the robustness and flexibility of what we have to offer.

Through the full integration of our platforms the Centre can provide a unique capability for complete “design, build, and test and re-design” cycles that apply predictive SynBio technologies towards bio-sustainable production of fine and speciality chemicals

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T.N.A. Offer

Users of the SYNBIOCHEM Centre facilties will benefit from access to broad equipment capabilities and know-how with training and technical support for development of novel SynBio solutions for the production of fine and speciality chemicals. Interactions will be on multiple levels, either accessing part of our technology platform (e.g. DESIGN: in silico design tools for pathway modelling; BUILD: Pathway assembly and High Throughput robotics platforms; TEST HTP robotic screening platforms or MS analysis) or benefiting from the integrated capabilities to take their experimental research challenges from in silico design through to in vivo build and test/re-design.

The type of access provided will depend upon the user. This may range from a short stay of a few days to gain training in a particular technique or run an experiment on a particular piece of instrumentation or for longer periods of up to 3 months to work in close collaboration with the Centre. The Centre will provide all the necessary office, laboratory and meeting space required for the collaboration in the MIB which is situated within walking distance of central Manchester

More Info

DESIGN: SYNBIOCHEM can provide access to an integrated suite of computational predictive modelling tools for: retrosynthesis, part to pathway scale modelling tools; chemical pathway and enzyme selection; DNA Bioblock and pathway design (Combinatorial design, Design of experiment sampling, Sequence creation and Assembly recipe)

BUILD: SYNBIOCHEM can provide access to a range of tools for directed evolution library assembly (SpeedyGenes), gene-editing, regulatory tools and chassis engineering, gene/DNA part compilation, part/pathway assembly and high throughput (HTP) robotics platforms for automated assembly, microbial growth and production

TEST: SYNBIOCHEM can provide access to high-throughput screening methods and a suite of state-of-the-art Mass Spectrometers (MS) which provides high sensitivity, resolution and mass accuracy chemical detection with broad capabilities for compound analysis and multiple dimension separation, supporting both targeted analysis and untargeted metabolomics

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The  University of Manchester (UNIMAN) is the largest single-site university in the UK, with research strength across all scientific disciplines. In this proposal, UNMIAN is represented by the Manchester institute of Biotechnology (MIB) and by the School of Computer Science