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Dernière mise à jour : Mai 2018

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FR_INSAT-MetaToul-Fluxomics

Remote / On-site

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13-C Fluxomics

Flux Calculation

Modelisation

Metabolic Fluxes

FR_INSAT-MetaToul-Fluxomics

www.metatoul.fr

www.metabohub.fr

Units of access: Flux Map

Quantity offered: 2

Total offered: 2

About the Platform 

The MetaToul - Metabolic Networks platform dedicates its activities to the functional analysis of cellular metabolism. For this, the platform develops and applies methodologies combining mass spectrometry and nuclear magnetic resonance for the analysis of metabolic networks: 

- Quantitative targeted analyzes
- Identification of metabolic pathways by isotopic labeling (13C-Metabolomics)
- Measurement of metabolic fluxes (13C-Fluxomics)
- Modeling of metabolic systems (Flux calculation)

TNA Map France

T.N.A. Offer

Fluxomics is the measurement of the real speeds of metabolic reactions in the integrated biological system (intracellular/intratissular fluxes). 

There is no direct method to measure intracellular fluxes in a cell or tissues. The most relevant indirect approach is based on isotope labeling strategies, here 13C, coupled with fine analysis (measurement of "isotopomers") of isotopic incorporation into metabolites, performed either by mass spectrometry (MS) or by nuclear magnetic resonance (NMR). It leads to obtain flux maps that represent the quantitative distribution of the fluxes (here carbon) in the metabolic network of the biological system studied. 

Prerequisites: 

- Macrokinetic knowledge : consumption and production rates, biomass composition - Metabolic network knowledge : topology, enzymatic reactions, carbon transitions
- Intracellular pools from central metabolism
- Validation of sampling protocols for isotopic profiling by MS or NMR

More Info

The platform is ISO9001 NFX-50-900 certified and is part of the National Infrastructure of Metabolomic and Fluxomic METABOHUB

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LISBP

LISBP (The Biological Systems and Biochemical Engineering) is a Joint Research Unit (UMR) associated with INRA, CNRS, INSAT and located on the INSA-Toulouse Campus. Internationally recognised, the LISBP stands out as a pioneer for the innovative way it associates Life Sciences and Engineering Sciences, as well as for its advances in fundamental and applied Biology, Microbiology, Microbial Physiology and Metabolism, Engineering, Fermentation and Processes. The LISBP research work has very large applications in Industrial Biotechnology such as Bioenergy and Green Chemistry, Water Treatment, Food Processing and Health